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References.jpegCord Tissue Derived MSC Applications

This web page was researched by Dr Guy Moeneclaey, PhD, Scientific & Product Development Manager for CellCare. ©2018

For the purposes of this review -  

  • The Clinical Trial list was obtained from ClinicalTrials.gov and accessed on May 15-19, 2018
  • Publications/therapeutic applications retrieved from the online database PubMed (https://www.ncbi.nlm.nih.gov/pubmed/), accessed on May 15-19, 2018

All clinical trials have been listed excluding those identified as withdrawn or suspended.

The list is not exhaustive as preference has been given to therapeutic applications over clinical trials and pre-clinical research where available.

This list does not constitute medical advice. Please consult your physician for consideration of treatment options. For more information on any of the trials listed please follow the link for the specific trial and locate the contact information and address your query to the trial site directly. Abstracts of all publications are available on PubMed (https://www.ncbi.nlm.nih.gov/pubmed/). Full articles are available free of charge in some instances but may be premium content requiring payment for access.   

The views and opinions expressed in the trials and publications are those of the authors and do not necessarily reflect the position of the CellCare.

Some conditions have been combined under the specific organ affected; some variations of a disease or specific complications have been placed under the broader condition.

 

Condition

Clinical Trials

Pre-clinical research

Therapeutic applications

Rheumatoid Arthritis

YES

YES

YES

Multiple Sclerosis

YES

YES

 

Osteoarthritis of the Knee

YES

YES

 

Asthma

YES

YES

 

Burn Wounds

YES

YES

 

Systemic Lupus Erythematosus

YES

 

YES

Cerebral Palsy

YES

 

YES

Stroke

YES

 

YES

Type 1 Diabetes

YES

 

YES

Liver Fibrosis

YES

 

YES

Cartilage Injury

YES

 

YES

Parkinson’s Disease

YES

YES

 

Spinal Cord Injury

 

 

YES

Spinocerebellar Ataxia

 

 

YES

Nerve Injury

 

 

YES

Cerebral Haemorrhage

 

 

YES

Traumatic Brain Injury

 

 

YES

Autism

 

 

YES

Hypoxic-ischemic encephalopathy (HIE)

 

 

YES

Vascular Dementia

 

 

YES

Bowel Disease

 

 

YES

Liver Cirrhosis, Injury, Failure & Transplantation

 

 

YES

Cardiovascular Disease

 

 

YES

Diabetes & Complications

 

 

YES

Muscular Dystrophies

 

 

YES

Bone healing

 

 

YES

Lung Injury

 

 

YES

Skin disorders and wound healing

 

 

YES

 

Definitions

  • Clinical Trials
  • Preclinical Research
  • Therapeutic Applications

 

Rheumatoid Arthritis

Includes Adult RA and Juvenile Refractory RA

Clinical Trials

Umbilical Cord Tissue-derived Mesenchymal Stem Cells for Rheumatoid Arthritis http://ClinicalTrials.gov/show/NCT01985464 (active, not recruiting)

Safety and Efficacy Study of Umbilical Cord-Derived Mesenchymal Stem Cells for Rheumatoid Arthritis http://ClinicalTrials.gov/show/NCT01547091 (status unknown)

Safety and Efficacy Study of Human Umbilical Cord-Mesenchymal Stem Cells for Rheumatoid Arthritis https://www.clinicaltrials.gov/ct2/show/NCT02643823 (status unknown)

Preclinical Research

Sun Y, Kong W, Huang S, et al.; Comparable therapeutic potential of umbilical cord mesenchymal stem cells in collagen-induced arthritis to TNF inhibitor or anti-CD20 treatment.; Clin Exp Rheumatol. 2017 Mar-Apr;35(2):288-295. Epub 2017 Jan 15.

Shin TH, Kim HS, Kang TW et al.; Human umbilical cord blood-stem cells direct macrophage polarization and block inflammasome activation to alleviate rheumatoid arthritis.; Cell Death Dis. 2016 Dec 22;7(12):e2524. doi: 10.1038/cddis.2016.442.

Park KH, Mun CH, Kang MI, et al.; Treatment of Collagen-Induced Arthritis Using Immune Modulatory Properties of Human Mesenchymal Stem Cells.; Cell Transplant. 2016;25(6):1057-72. doi: 10.3727/096368915X687949. Epub 2015 Apr 7.

Gu J, Gu W, Lin C, et al.; Human umbilical cord mesenchymal stem cells improve the immune-associated inflammatory and prothrombotic state in collagen type--induced arthritic rats.; Mol Med Rep. 2015 Nov;12(5):7463-70. doi: 10.3892/mmr.2015.4394. Epub 2015 Sep 30

Therapeutic Applications

Wang L, Zhang Y, Li H, et al.; Clinical Observation of Employment of Umbilical Cord Derived Mesenchymal Stem Cell for Juvenile Idiopathic Arthritis Therapy.; Stem Cells Int. 2016;2016:9165267. Doi: 10.1155/2016/9165267. Epub 2015 Dec 6.

Wang L1, Wang L, Cong X, et al.; Human umbilical cord mesenchymal stem cell therapy for patients with active rheumatoid arthritis: safety and efficacy.; Stem Cells Dev. 2013 Dec 15;22(24):3192-202. Doi: 10.1089/scd.2013.0023. Epub 2013 Oct 4.

 

Multiple Sclerosis

Includes progressive and relapsing/remitting

Clinical Trials

Feasibility Study of Human Umbilical Cord Tissue-Derived Mesenchymal Stem Cells in Patients With Multiple Sclerosis; https://www.clinicaltrials.gov/ct2/show/NCT02034188 (completed)

Phase I/II Study of Umbilical Cord Mesenchymal Stem Cell Therapy for Patients With Progressive Multiple Sclerosis and Neuromyelitis Optica; https://www.clinicaltrials.gov/ct2/show/NCT01364246 (status unknown)

The Effect of Stem Cell Therapy and Comprehensive Physical Therapy in Motor and Non-Motor Symptoms in Patients With Multiple Sclerosis: A Comparative Study; https://www.clinicaltrials.gov/ct2/show/NCT03326505 (recruiting)

An Open-label, Non-randomized, Phase I/II Study of Allogeneic Human Umbilical Cord Tissue-Derived Mesenchymal Stem Cells (UC-MSC) and Liberation Therapy (When Associated With Chronic Cerebrovascular Venous Insufficiency) in Patients With Relapsing Remitting Multiple Sclerosis (RRMS); https://www.clinicaltrials.gov/ct2/show/NCT02587715 (status unknown)

An Open-label, Non-randomized, Phase I/II Study of Allogeneic Human Umbilical Cord Tissue-Derived Mesenchymal Stem Cells (UC-MSC) and Liberation Therapy (When Associated With Chronic Cerebrovascular Venous Insufficiency) in Patients With Relapsing Remitting Multiple Sclerosis (RRMS); https://www.clinicaltrials.gov/ct2/show/NCT02418325 (terminated)

Therapeutic Applications

Riordan NH, Morales I, Fernández G, et al.; Clinical feasibility of umbilical cord tissue-derived mesenchymal stem cells in the treatment of multiple sclerosis.; J Transl Med. 2018 Mar 9;16(1):57. doi: 10.1186/s12967-018-1433-7.

Meng M, Liu Y, Wang W, et al.; Umbilical cord mesenchymal stem cell transplantation in the treatment of multiple sclerosis.; Am J Transl Res. 2018 Jan 15;10(1):212-223. eCollection 2018.

Li JF, Zhang DJ, Geng T, et al.; The potential of human umbilical cord-derived mesenchymal stem cells as a novel cellular therapy for multiple sclerosis.; Cell Transplant. 2014;23 Suppl 1:S113-22. doi: 10.3727/096368914X685005. Epub 2014 Nov 5.

Hou ZL, Liu Y, Mao XH et al.; Transplantation of umbilical cord and bone marrow-derived mesenchymal stem cells in a patient with relapsing-remitting multiple sclerosis.; Cell Adh Migr. 2013 Sep-Oct;7(5):404-7. doi: 10.4161/cam.26941. Epub 2013 Oct 30.

Liang J, Zhang H, Hua B, et al.; Allogeneic mesenchymal stem cells transplantation in treatment of multiple sclerosis.; Mult Scler. 2009 May;15(5):644-6. doi: 10.1177/1352458509104590.

 

Osteoarthritis of the knee

 

Clinical Trials

A Clinical Research on the Safety/Efficacy of Human Umbilical Cord Mesenchymal Stem Cells Therapy for Patients With Osteoarthritis; https://www.clinicaltrials.gov/ct2/show/NCT03383081 (not yet recruiting)

Clinical Study of Umbilical Cord Mesenchymal Stem Cells (UC-MSC) for Treatment of Knee Osteoarthritis; https://www.clinicaltrials.gov/ct2/show/NCT03166865 (recruiting)

Evaluating the Safety and Efficacy of Mesenchymal Stem Cells From Umbilical Cord in the Treatment of Knee Joint Osteoarthritis; https://www.clinicaltrials.gov/ct2/show/NCT03358654 (not yet recruiting)

Evaluating the Maximum Tolerated Dose of Mesenchymal Stem Cells From Umbilical; https://www.clinicaltrials.gov/ct2/show/NCT03357770 (not yet recruiting)

Effect of Implanting Allogenic Cytokines Derived From Human Amniotic Membrane (HAM) and Mesenchymal Stem Cells Derived From Human Umbilical Cord Wharton's Jelly (HUMCWJ) on Pain and Functioning of Knee Osteoarthritis; https://www.clinicaltrials.gov/ct2/show/NCT03337243 (recruiting)

Phase I/II Study of Umbilical Cord Mesenchymal Stem Cell Implantation in the Treatment of Articular Cartilage Defect of Knee and Knee Osteoarthritis; https://www.clinicaltrials.gov/ct2/show/NCT02776943 (not yet recruiting)

Phase I Study of Human Umbilical Cord Mesenchymal Stem Cell Implantation in the Treatment of Articular Cartilage Defect of Knee; https://www.clinicaltrials.gov/ct2/show/NCT02291926 (completed)

Therapeutic Applications

Sadlik B, Jaroslawski G, Gladysz D, et al.; Knee Cartilage Regeneration with Umbilical Cord Mesenchymal Stem Cells Embedded in Collagen Scaffold Using Dry Arthroscopy Technique.; Adv Exp Med Biol. 2017;1020:113-122. doi: 10.1007/5584_2017_9.

Park YB, Ha CW, Lee CH, et al.; Cartilage Regeneration in Osteoarthritic Patients by a Composite of Allogeneic Umbilical Cord Blood-Derived Mesenchymal Stem Cells and Hyaluronate Hydrogel: Results from a Clinical Trial for Safety and Proof-of-Concept with 7 Years of Extended Follow-Up.; Stem Cells Transl Med. 2017 Feb;6(2):613-621. doi: 10.5966/sctm.2016-0157. Epub 2016 Sep 9.

Sadlik B, Jaroslawski G, Puszkarz M, et al.; Cartilage Repair in the Knee Using Umbilical Cord Wharton's Jelly-Derived Mesenchymal Stem Cells Embedded Onto Collagen Scaffolding and Implanted Under Dry Arthroscopy.; Arthrosc Tech. 2017 Dec 25;7(1):e57-e63. doi: 10.1016/j.eats.2017.08.055. eCollection 2018 Jan.

 

Liver Transplantation

 

Clinical Trials

Human Umbilical Cord Mesenchymal Stem Cell Induce Liver Allografts Tolerance; https://www.clinicaltrials.gov/ct2/show/NCT01690247 (status: unknown)

Therapeutic Applications

Shi M, Liu Z, Wang Y et al.; A Pilot Study of Mesenchymal Stem Cell Therapy for Acute Liver Allograft Rejection.; Stem Cells Transl Med. 2017 Dec;6(12):2053-2061. doi: 10.1002/sctm.17-0134.

Zhang YC, Liu W, Fu BS, et al.; Therapeutic potentials of umbilical cord-derived mesenchymal stromal cells for ischemic-type biliary lesions following liver transplantation.; Cytotherapy. 2017 Feb;19(2):194-199. doi: 10.1016/j.jcyt.2016.11.005. Epub 2016 Dec 8.

 

Asthma

 

Clinical Trials

Safety and Feasibility Study of Intranasal Mesenchymal Trophic Factor (MTF) for Treatment of Asthma; https://www.clinicaltrials.gov/ct2/show/NCT02192736 (active, not recruiting)

Preclinical Research

Moradi M, Rezaee MA, Mohammadi M, et al.; Attenuating Effect of Long-term Culture of Umbilical Cord Vein Mesenchymal Stromal Cells on Pulmonary Fibrosis in C57BL/6 Mice.; Iran J Allergy Asthma Immunol. 2017 Dec;16(6):501-510

Ren NN, Chen HJ, Chen QL, et al.; Effects of human mesenchymal stem cells on airway inflammation in allergic asthma mice and the underlying mechanism; Zhonghua Yi Xue Za Zhi. 2017 Sep 12;97(34):2697-2702. doi: 10.3760/cma.j.issn.0376-2491.2017.34.012

Kang SY, Park DE, Song WJ, et al,; Immunologic regulatory effects of human umbilical cord blood-derived mesenchymal stem cells in a murine ovalbumin asthma model.; Clin Exp Allergy. 2017 Jul;47(7):937-945. doi: 10.1111/cea.12920. Epub 2017 May 11.

Chan CK, Lin TC, Huang YA, et al.; The modulation of Th2 immune pathway in the immunosuppressive effect of human umbilical cord mesenchymal stem cells in a murine asthmatic model.; Inflamm Res. 2016 Oct;65(10):795-801. doi: 10.1007/s00011-016-0961-y. Epub 2016 Jul 6.

 

Burn Wounds

Clinical Trials

A Phase Ι/Π Study of Human Cord Blood Mononuclear Cells and Human Umbilical Cord Mesenchymal Stem Cells Transplantation in Patients With Acute Burn; https://www.clinicaltrials.gov/ct2/show/NCT01443689 (status: unknown)

Placebo-Controlled, Randomized, Double-blind Trial of Umbilical Cord Mesenchymal Stem Cells Injection for Ocular Corneal Burn; https://www.clinicaltrials.gov/ct2/show/NCT03237442 (not yet recruiting)

A Phase Ι/Π Study of Human Cord Blood Mononuclear Cells and Human Umbilical Cord Mesenchymal Stem Cells Transplantation in Patients With Acute Burn; https://www.clinicaltrials.gov/ct2/show/NCT01443689 (status: unknown)

Safety and Exploratory Efficacy Study of Collagen Membrane With Mesenchymal Stem Cells in the Treatment of Skin Defects (SEESCMMSCTSD); https://www.clinicaltrials.gov/ct2/show/NCT02672280 (status: unknown)

Preclinical Research

Liu Z, Yu D, Xu J, et al.; Human umbilical cord mesenchymal stem cells improve irradiation-induced skin ulcers healing of rat models.; Biomed Pharmacother. 2018 May;101:729-736. doi: 10.1016/j.biopha.2018.02.093. Epub 2018 Mar 22.

Montanucci P, di Pasquali C, Ferri I, et al.; Human Umbilical Cord Wharton Jelly-Derived Adult Mesenchymal Stem Cells, in Biohybrid Scaffolds, for Experimental Skin Regeneration.; Stem Cells Int. 2017;2017:1472642. doi: 10.1155/2017/1472642. Epub 2017 Dec 31

Sharma N, Kaur M, Agarwal T, et al.; Treatment of acute ocular chemical burns.; Surv Ophthalmol. 2018 Mar - Apr;63(2):214-235. doi: 10.1016/j.survophthal.2017.09.005. Epub 2017 Sep 19. Review

Wang Y, Hu X.; Advance on human umbilical cord mesenchymal stem cells for treatment of ALI in severe burns].; Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017 Jan;29(1):90-96. doi: 10.3760/cma.j.issn.2095-4352.2017.01.020.

Zhang J, La X, Fan L, et al.; Immunosuppressive effects of mesenchymal stem cell transplantation in rat burn models.; Int J Clin Exp Pathol. 2015 May 15;8(5):5129-36. eCollection 2015.

 

Systemic Lupus Erythematosus

 

Clinical Trials

Evaluation of Safety and Efficacy in Patients With Systemic Lupus Erythematosus by Transplantation of Umbilical Cord Derived Mesenchymal Stem Cells; https://www.clinicaltrials.gov/ct2/show/NCT03219801 (not yet recruiting)

Clinical Study of Umbilical Cord Mesenchymal Stem Cell Transplantation for Lupus Nephritis; https://www.clinicaltrials.gov/ct2/show/NCT03458156 (active, not recruiting)

Phase I/II: Umbilical Cord Derived Mesenchymal Stem Cells Transplantation For Active And Refractory Systemic Lupus Erythematosus; https://www.clinicaltrials.gov/ct2/show/NCT01741857 (status: unknown)

A Randomized, Double Blind, Parallel Group, Placebo Controlled Research of Human Umbilical Cord Derived Mesenchymal Stem Cell for the Treatment of Lupus Nephritis; https://www.clinicaltrials.gov/ct2/show/NCT01539902 (status: unknown)

A Phase I Safety Trial of Allogeneic Mesenchymal Stem Cells for Systemic Lupus Erythematosus; https://www.clinicaltrials.gov/ct2/show/NCT03171194 (active, not recruiting)

A Phase II Controlled Trial of Allogeneic Mesenchymal Stem Cells for the Treatment of Refractory Lupus; https://www.clinicaltrials.gov/ct2/show/NCT02633163 (not yet recruiting)

Evaluation of Safety and Efficacy in Patients With Systemic Lupus Erythematosus by Transplantation of Umbilical Cord Derived Mesenchymal Stem Cells; https://www.clinicaltrials.gov/ct2/show/NCT03219801 (not yet recruiting)

Clinical Study of Umbilical Cord Mesenchymal Stem Cell Transplantation for Lupus Nephritis; https://www.clinicaltrials.gov/ct2/show/NCT03458156 (active, not recruiting)

Phase I/II: Umbilical Cord Derived Mesenchymal Stem Cells Transplantation For Active And Refractory Systemic Lupus Erythematosus; https://www.clinicaltrials.gov/ct2/show/NCT01741857 (status: unknown)

A Randomized, Double Blind, Parallel Group, Placebo Controlled Research of Human Umbilical Cord Derived Mesenchymal Stem Cell for the Treatment of Lupus Nephritis; https://www.clinicaltrials.gov/ct2/show/NCT01539902 (status: unknown)

A Phase I Safety Trial of Allogeneic Mesenchymal Stem Cells for Systemic Lupus Erythematosus; https://www.clinicaltrials.gov/ct2/show/NCT03171194 (active, not recruiting)

A Phase II Controlled Trial of Allogeneic Mesenchymal Stem Cells for the Treatment of Refractory Lupus; https://www.clinicaltrials.gov/ct2/show/NCT02633163 (not yet recruiting)

Therapeutic Applications

Phillips CD, Wongsaisri P, Htut T, et al.; Purified umbilical cord derived mesenchymal stem cell treatment in a case of systemic lupus erythematosus.; Clin Transl Med. 2017 Dec;6(1):31. doi: 10.1186/s40169-017-0161-6. Epub 2017 Aug 7.

Wang D, Niu L, Feng X, et al.; Long-term safety of umbilical cord mesenchymal stem cells transplantation for systemic lupus erythematosus: a 6-year follow-up study.; lin Exp Med. 2017 Aug;17(3):333-340. doi: 10.1007/s10238-016-0427-0. Epub 2016 Jun 7.

Wang D, Zhang H, Liang J, et al.; A Long-Term Follow-Up Study of Allogeneic Mesenchymal Stem/Stromal Cell Transplantation in Patients with Drug-Resistant Systemic Lupus Erythematosus.; Stem Cell Reports. 2018 Mar 13;10(3):933-941. doi: 10.1016/j.stemcr.2018.01.029. Epub 2018 Mar 1

Deng D, Zhang P, Guo Y, et al.; A randomised double-blind, placebo-controlled trial of allogeneic umbilical cord-derived mesenchymal stem cell for lupus nephritis.; Ann Rheum Dis. 2017 Aug;76(8):1436-1439. doi: 10.1136/annrheumdis-2017-211073. Epub 2017 May 6

Gu F, Wang D, Zhang H, et al.; Allogeneic mesenchymal stem cell transplantation for lupus nephritis patients refractory to conventional therapy.; Clin Rheumatol. 2014 Nov;33(11):1611-9. doi: 10.1007/s10067-014-2754-4. Epub 2014 Aug 14.

 

Cerebral Palsy

 

Includes acute brain injury leading to CP and a variety of ages of the recipient

Clinical Trials

Efficacy of Stem Cell Transplantation Compared to Rehabilitation Treatment of Children With Cerebral Paralysis; https://www.clinicaltrials.gov/ct2/show/NCT01929434 (completed)

Comparing of effect of umbilical cord mesenchymal stem cell therapy on motor function of twin cerebral palsy; http://www.chictr.org.cn/showprojen.aspx?proj=6435 (completed)

Therapeutic Applications

Okur SÇ, Erdoğan S, Demir CS, et al.; The Effect of Umbilical Cord-derived Mesenchymal Stem Cell Transplantation in a Patient with Cerebral Palsy: A Case Report.; Int J Stem Cells. 2018 Apr 30. doi: 10.15283/ijsc17077. [Epub ahead of print]

Dong H, Li G, Shang C, et al.; Umbilical cord mesenchymal stem cell (UC-MSC) transplantations for cerebral palsy.; Am J Transl Res. 2018 Mar 15;10(3):901-906. eCollection 2018

Huang L, Zhang C, Gu J, et al.; A Randomized, Placebo-Controlled Trial of Human Umbilical Cord Blood Mesenchymal Stem Cell Infusion for Children With Cerebral Palsy.; Cell Transplant. 2018 Feb;27(2):325-334. doi: 10.1177/0963689717729379

Miao X, Wu X, Shi W.; Umbilical cord mesenchymal stem cells in neurological disorders: A clinical study.; Indian J Biochem Biophys. 2015 Apr;52(2):140-6

Zhang C, Huang L, Gu J, et al.; Therapy for Cerebral Palsy by Human Umbilical Cord Blood Mesenchymal Stem Cells Transplantation Combined With Basic Rehabilitation Treatment: A Case Report.; Glob Pediatr Health. 2015 Mar 5;2:2333794X15574091. doi: 10.1177/2333794X15574091. eCollection 2015

Wang X, Hu H, Hua R, et al.; Effect of umbilical cord mesenchymal stromal cells on motor functions of identical twins with cerebral palsy: pilot study on the correlation of efficacy and hereditary factors.; Cytotherapy. 2015 Feb;17(2):224-31. doi: 10.1016/j.jcyt.2014.09.010

Wang L, Ji H, Zhou J, et al.; Therapeutic potential of umbilical cord mesenchymal stromal cells transplantation for cerebral palsy: a case report.; Case Rep Transplant. 2013;2013:146347. doi: 10.1155/2013/146347. Epub 2013 Mar 3.

 

Stroke

Includes haemorrhagic and ischaemic stroke, acute and chronic phase intervention and adult stroke and perinatal stroke.

Clinical Trials

Cell Therapy by Intravenous Injection of Umbilical Cord Derived Mesenchymal Stem Cells After Stroke; https://www.clinicaltrials.gov/ct2/show/NCT02580019 (status: unknown)

Study the Safety and Efficacy of Human Umbilical Cord-derived Mesenchymal Stem Cells in the Treatment of Acute Cerebral Infarction; https://www.clinicaltrials.gov/ct2/show/NCT03186456 (not yet recruiting)

The Effects of Human Umbilical Cord Mesenchymal Stem Cell Therapy on Neurological Function for Cerebral Infarction Patients in Convalescent Period.; https://www.clinicaltrials.gov/ct2/show/NCT03176498 (not yet recruiting)

A Randomized, Double-blind, Placebo-controlled, Phase I / IIa Clinical Trial for Evaluation of the Safety and Potential Therapeutic Effects After Intravenous Transplantation of Human Umbilical Cord-derived Mesenchymal Stem Cells in Patients With Cerebral Infarction; https://www.clinicaltrials.gov/ct2/show/NCT02378974 (active, not yet recruiting)

Therapeutic Application – Haemorrhagic Stroke

Chang Z, Mao G, Sun L et al.; Cell therapy for cerebral hemorrhage: Five year follow-up report.; Exp Ther Med. 2016 Dec;12(6):3535-3540. doi: 10.3892/etm.2016.3811. Epub 2016 Oct 18

Therapeutic Application -Stroke – Chronic Phase

Chen L, Xi H, Huang H, et al.; Multiple cell transplantation based on an intraparenchymal approach for patients with chronic phase stroke.; Cell Transplant. 2013;22 Suppl 1:S83-91. Doi: 10.3727/096368913X672154. Epub 2013 Aug 29.

Therapeutic Application – Haemorrhagic and ischaemic Stroke

Jiang Y, Zhu W, Zhu J, et al.; Feasibility of delivering mesenchymal stem cells via catheter to the proximal end of the lesion artery in patients with stroke in the territory of the middle cerebral artery.; Cell Transplant. 2013;22(12):2291-8. doi: 10.3727/096368912X658818. Epub 2012 Nov 1.

 

Type I Diabetes

 

Clinical Trials

Umbilical Mesenchymal Stem Cells and Mononuclear Cells Infusion in Type 1 Diabetes Mellitus: A Randomized Controlled Open-label Study; https://www.clinicaltrials.gov/ct2/show/NCT01374854 (treatment; status: unknown)

Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cells Infusion for Initial Type 1 Diabetes; https://www.clinicaltrials.gov/ct2/show/NCT01219465 (treatment; status: unknown)

The Efficacy of Allogeneic Umbilical Cord Mesenchymal Stem Cell Transplantation to Treat New-onset Type 1 Diabetes With Diabetic Ketoacidosis; https://www.clinicaltrials.gov/ct2/show/NCT02763423 (treatment; recruiting)

A Pilot Study on Transplantation Therapy Using Autologous Bone Marrow Mononuclear Cells and Umbilical Cord Mesenchymal Stem Cells in Patients With Type 1 Diabetes Mellitus; https://www.clinicaltrials.gov/ct2/show/NCT01143168 (treatment; status: unknown)

A Preliminary Safety and Efficacy Evaluation of Mesenchymal Stem Cell Transplantation for Type 1 Diabetes Mellitus (T1DM) Patients; https://www.clinicaltrials.gov/ct2/show/NCT03484741 (treatment; recruiting)

Therapeutic Applications

Cai J, Wu Z, Xu X, et al.; Umbilical Cord Mesenchymal Stromal Cell With Autologous Bone Marrow Cell Transplantation in Established Type 1 Diabetes: A Pilot Randomized Controlled Open-Label Clinical Study to Assess Safety and Impact on Insulin Secretion.; Diabetes Care. 2016 Jan;39(1):149-57. doi: 10.2337/dc15-0171. Epub 2015 Dec 1

Hu J, Yu X, Wang Z, et al.; Long term effects of the implantation of Wharton's jelly-derived mesenchymal stem cells from the umbilical cord for newly-onset type 1 diabetes mellitus.; Endocr J. 2013;60(3):347-57. Epub 2012 Nov 16.

 

Liver Fibrosis

 

Clinical Trials

Clinical Trial of Umbilical Mesenchymal Stem Cells Transplantation for Liver Cirrhosis-Phase I/II; https://www.clinicaltrials.gov/ct2/show/NCT01573923 (status: unknown)

Phase Ι/Π Study of Human Umbilical Cord Mesenchymal Stem Cells Transplantation for Patients With Decompensated Liver Cirrhosis; https://www.clinicaltrials.gov/ct2/show/NCT01342250 (completed)

The Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cells Infusion Via Hepatic Artery in Cirrhosis Patients; https://www.clinicaltrials.gov/ct2/show/NCT01224327 (status: unknown)

Role of Bone Marrow Derived Autologous Stem Cells + Human Umbilical Cord Derived Mesenchymal Stem Cells for the Treatment of Liver Cirrhosis; https://www.clinicaltrials.gov/ct2/show/NCT01877759 (status: unknown)

Safety and Efficacy of Human Umbilical Cord Derived Mesenchymal Stem Cells for Treatment of HBV-related Liver Cirrhosis; https://www.clinicaltrials.gov/ct2/show/NCT01728727 (status: unknown)

Phase 1/2 Study of UC-MSC Treatment for the Evaluation the Efficacy and Safety in Patients With Liver Cirrhosis; https://www.clinicaltrials.gov/ct2/show/NCT01220492 (status: unknown)

Therapeutic Applications

Fang X, Liu L, Dong J et al.; A study about immunomodulatory effect and efficacy and prognosis of human umbilical cord mesenchymal stem cells in patients with chronic hepatitis B-induced decompensated liver cirrhosis.; J Gastroenterol Hepatol. 2018 Apr;33(4):774-780. doi: 10.1111/jgh.14081.

Sang W, Lv B, Li K, et al.; Therapeutic efficacy and safety of umbilical cord mesenchymal stem cell transplantation for liver cirrhosis in Chinese population: A meta-analysis.; Clin Res Hepatol Gastroenterol. 2017 Dec 6. pii: S2210-7401(17)30259-0. doi: 10.1016/j.clinre.2017.11.003. [Epub ahead of print]

Liang J, Zhang H, Zhao C, et al.; Effects of allogeneic mesenchymal stem cell transplantation in the treatment of liver cirrhosis caused by autoimmune diseases.; Int J Rheum Dis. 2017 Sep;20(9):1219-1226. doi: 10.1111/1756-185X.13015. Epub 2017 Feb 20.

Yu SJ, Chen LM, Lyu S et al.; Safety and efficacy of human umbilical cord derived-mesenchymal stem cell transplantation for treating patients with HBV-related decompensated cirrhosis.; Zhonghua Gan Zang Bing Za Zhi. 2016 Jan;24(1):51-5. doi: 10.3760/cma.j.issn.1007-3418.2016.01.010.

Xue HL, Zeng WZ, Wu XL et al.; Clinical therapeutic effects of human umbilical cord-derived mesenchymal stem cells transplantation in the treatment of end-stage liver disease.; Transplant Proc. 2015 Mar;47(2):412-8. doi: 10.1016/j.transproceed.2014.10.048.

Wang L, Li J, Liu H, et al.; Pilot study of umbilical cord-derived mesenchymal stem cell transfusion in patients with primary biliary cirrhosis.; J Gastroenterol Hepatol. 2013 Aug;28 Suppl 1:85-92. doi: 10.1111/jgh.12029

Lin H, Zhang Z, Shi M, et al.; Prospective controlled trial of safety of human umbilical cord derived-mesenchymal stem cell transplantation in patients with decompensated liver cirrhosis.; Zhonghua Gan Zang Bing Za Zhi. 2012 Jul;20(7):487-91. doi: 10.3760/cma.j.issn.1007-3418.2012.07.002.

Zhang Z, Lin H, Shi M, et al.; Human umbilical cord mesenchymal stem cells improve liver function and ascites in decompensated liver cirrhosis patients.; J Gastroenterol Hepatol. 2012 Mar;27 Suppl 2:112-20. doi: 10.1111/j.1440-1746.2011.07024.x

 

Cartilage

Clinical Trials

Phase I Study of Human Umbilical Cord Mesenchymal Stem Cell Implantation in the Treatment of Articular Cartilage Defect of Knee; https://www.clinicaltrials.gov/ct2/show/NCT02291926 (completed)

Phase I/II Study of Umbilical Cord Mesenchymal Stem Cell Implantation in the Treatment of Articular Cartilage Defect of Knee and Knee Osteoarthritis; https://www.clinicaltrials.gov/ct2/show/NCT02776943 (not yet recruiting)

Evaluation of Safety and Exploratory Efficacy of CARTISTEM®, a Cell Therapy Product for Articular Cartilage Defects: A Phase I/IIa Clinical Trial in Patients With Focal, Full-thickness Grade 3-4 Articular Cartilage Defects of the Knee; https://www.clinicaltrials.gov/ct2/show/NCT01733186 (completed)

Randomized, Open-Label, Multi-Center and Phase 3 Clinical Trial to Compare the Efficacy and Safety of Cartistem® and Microfracture in Patients With Knee Articular Cartilage Injury or Defect; https://www.clinicaltrials.gov/ct2/show/NCT01041001 (completed)

Long Term Follow-Up Study of CARTISTEM® Versus Microfracture for the Treatment of Knee; https://www.clinicaltrials.gov/ct2/show/NCT01626677 (completed)

Therapeutic Applications

Sadlik B, Jaroslawski G, Puszkarz M, et al.; Cartilage Repair in the Knee Using Umbilical Cord Wharton's Jelly-Derived Mesenchymal Stem Cells Embedded Onto Collagen Scaffolding and Implanted Under Dry Arthroscopy.; Arthrosc Tech. 2017 Dec 25;7(1):e57-e63. doi: 10.1016/j.eats.2017.08.055. eCollection 2018 Jan

Park YB, Ha CW, Lee CH, et al.; Restoration of a large osteochondral defect of the knee using a composite of umbilical cord blood-derived mesenchymal stem cells and hyaluronic acid hydrogel: a case report with a 5-year follow-up.; BMC Musculoskelet Disord. 2017 Feb 2;18(1):59. doi: 10.1186/s12891-017-1422-7.

Park YB, Ha CW, Lee CH, et al.; Cartilage Regeneration in Osteoarthritic Patients by a Composite of Allogeneic Umbilical Cord Blood-Derived Mesenchymal Stem Cells and Hyaluronate Hydrogel: Results from a Clinical Trial for Safety and Proof-of-Concept with 7 Years of Extended Follow-Up.; Stem Cells Transl Med. 2017 Feb;6(2):613-621. doi: 10.5966/sctm.2016-0157. Epub 2016 Sep 9

Sadlik B, Jaroslawski G, Gladysz D, et al.; Knee Cartilage Regeneration with Umbilical Cord Mesenchymal Stem Cells Embedded in Collagen Scaffold Using Dry Arthroscopy Technique.; Adv Exp Med Biol. 2017;1020:113-122. doi: 10.1007/5584_2017_9

 

Parkinson’s Disease

 

Preclinical Research

Aliaghaei A, Gardaneh M, Maghsoudi N, et al.; Dopaminergic Induction of Umbilical Cord Mesenchymal Stem Cells by Conditioned Medium of Choroid Plexus Epithelial Cells Reduces Apomorphine-Induced Rotation in Parkinsonian Rats.; Arch Iran Med. 2016 Aug;19(8):561-70. doi: 0161908/AIM.008

Wang Z, Chen A, Yan S, et al.; Study of differentiated human umbilical cord-derived mesenchymal stem cells transplantation on rat model of advanced parkinsonism.; Cell Biochem Funct. 2016 Aug;34(6):387-93. doi: 10.1002/cbf.3204

Yan M, Sun M, Zhou Y, et al.; Conversion of human umbilical cord mesenchymal stem cells in Wharton's jelly to dopamine neurons mediated by the Lmx1a and neurturin in vitro: potential therapeutic application for Parkinson's disease in a rhesus monkey model.; PLoS One. 2013 May 28;8(5):e64000. doi: 10.1371/journal.pone.0064000. Print 2013

Shetty P, Thakur AM, Viswanathan C.; Dopaminergic cells, derived from a high efficiency differentiation protocol from umbilical cord derived mesenchymal stem cells, alleviate symptoms in a Parkinson's disease rodent model.; Cell Biol Int. 2013 Feb;37(2):167-80. doi: 10.1002/cbin.10029

Aliaghaei A, Gardaneh M, Maghsoudi N, et al.; Dopaminergic Induction of Umbilical Cord Mesenchymal Stem Cells by Conditioned Medium of Choroid Plexus Epithelial Cells Reduces Apomorphine-Induced Rotation in Parkinsonian Rats.; Arch Iran Med. 2016 Aug;19(8):561-70. doi: 0161908/AIM.008

Wang Z, Chen A, Yan S, et al.; Study of differentiated human umbilical cord-derived mesenchymal stem cells transplantation on rat model of advanced parkinsonism.; Cell Biochem Funct. 2016 Aug;34(6):387-93. doi: 10.1002/cbf.3204

Yan M, Sun M, Zhou Y, et al.; Conversion of human umbilical cord mesenchymal stem cells in Wharton's jelly to dopamine neurons mediated by the Lmx1a and neurturin in vitro: potential therapeutic application for Parkinson's disease in a rhesus monkey model.; PLoS One. 2013 May 28;8(5):e64000. doi: 10.1371/journal.pone.0064000. Print 2013

Shetty P, Thakur AM, Viswanathan C.; Dopaminergic cells, derived from a high efficiency differentiation protocol from umbilical cord derived mesenchymal stem cells, alleviate symptoms in a Parkinson's disease rodent model.; Cell Biol Int. 2013 Feb;37(2):167-80. doi: 10.1002/cbin.10029

 

In vitro Research

Boroujeni ME, Gardaneh M.; Umbilical cord: an unlimited source of cells differentiable towards dopaminergic neurons.; Neural Regen Res. 2017 Jul;12(7):1186-1192. doi: 10.4103/1673-5374.211201. Review

Yang S, Sun HM, Yan JH, et al.; Conditioned medium from human amniotic epithelial cells may induce the differentiation of human umbilical cord blood mesenchymal stem cells into dopaminergic neuron-like cells.; J Neurosci Res. 2013 Jul;91(7):978-86. doi: 10.1002/jnr.23225. Epub 2013 Apr 30

Xiong N, Zhang Z, Huang J, et al.; VEGF-expressing human umbilical cord mesenchymal stem cells, an improved therapy strategy for Parkinson's disease.; Gene Ther. 2011 Apr;18(4):394-402. doi: 10.1038/gt.2010.152. Epub 2010 Nov 25

 

UCT-derived MSC for Spinal Cord Injury

Therapeutic Applications

Zhao Y, Tang F, Xiao Z, et al.; Clinical Study of NeuroRegen Scaffold Combined With Human Mesenchymal Stem Cells for the Repair of Chronic Complete Spinal Cord Injury.; Cell Transplant. 2017 May 9;26(5):891-900. doi: 10.3727/096368917X695038. Epub 2017 Feb 9.

Cheng H, Liu X, Hua R, et al.; Clinical observation of umbilical cord mesenchymal stem cell transplantation in treatment for sequelae of thoracolumbar spinal cord injury.; J Transl Med. 2014 Sep 12;12:253. doi: 10.1186/s12967-014-0253-7

Liu J, Han D, Wang Z, et al.; Clinical analysis of the treatment of spinal cord injury with umbilical cord mesenchymal stem cells.; Cytotherapy. 2013 Feb;15(2):185-91. doi: 10.1016/j.jcyt.2012.09.005.

Hua R, Li P, Wang X, et al.; Evaluation of somatosensory evoked potential and pain rating index in a patient with spinal cord injury accepted cell therapy.; Pain Physician 2016;19:E659–66

 

UCT-derived MSC for Spinocerebellar Ataxia

Therapeutic Applications

Jin JL, Liu Z, Lu ZJ, et al.; Safety and efficacy of umbilical cord mesenchymal stem cell therapy in hereditary spinocerebellar ataxia.;  Curr Neurovasc Res. 2013 Feb;10(1):11-20

Dongmei H, Jing L, Mei X, et al.; Clinical analysis of the treatment of spinocerebellar ataxia and multiple system atrophy-cerebellar type with umbilical cord mesenchymal stromal cells.; Cytotherapy. 2011 Sep;13(8):913-7. doi: 10.3109/14653249.2011.579958. Epub 2011 May 5

Miao X, Wu X, Shi W.; Umbilical cord mesenchymal stem cells in neurological disorders: A clinical study.; Indian J Biochem Biophys. 2015 Apr;52(2):140-6.

 

UCT-derived MSC for Nerve Injury

Therapeutic Applications

Fang JF, Huang XN, Han XY, et al.; Combined Transplantation of Mesenchymal Stem Cells and Endothelial Progenitor Cells Restores Cavernous Nerve Injury-Related Erectile Dysfunction.; J Sex Med. 2018 Mar;15(3):284-295. doi: 10.1016/j.jsxm.2018.01.005.

Li Z, Qin H, Feng Z, et al.; Human umbilical cord mesenchymal stem cell-loaded amniotic membrane for the repair of radial nerve injury.; Neural Regen Res. 2013 Dec 25;8(36):3441-8. doi: 10.3969/j.issn.1673-5374.2013.36.010.

Xue G, He M, Zhao J, et al.; Intravenous umbilical cord mesenchymal stem cell infusion for the treatment of combined malnutrition nonunion of the humerus and radial nerve injury.; Regen Med. 2011 Nov;6(6):733-41. doi: 10.2217/rme.11.83.

Lu Z, Ye D, Qian L, et al.; Human umbilical cord mesenchymal stem cell therapy on neuromyelitis optica.; Curr Neurovasc Res. 2012 Nov;9(4):250-5.

Liang J, Wang F, Wang D, et al.; Transplantation of mesenchymal stem cells in a laryngeal carcinoma patient with radiation myelitis.; Stem Cell Res Ther. 2015 Nov 4;6:213. doi: 10.1186/s13287-015-0203-1.

 

UCT-derived MSC for Cerebral Haemorrhage

Therapeutic Applications

Chang Z, Mao G, Sun L, et al.; Cell therapy for cerebral hemorrhage: Five year follow-up report.; Exp Ther Med. 2016 Dec;12(6):3535-3540. doi: 10.3892/etm.2016.3811. Epub 2016 Oct 18

Chen L, Xi H, Huang H, et al.; Multiple cell transplantation based on an intraparenchymal approach for patients with chronic phase stroke.; Cell Transplant. 2013;22 Suppl 1:S83-91. doi: 10.3727/096368913X672154. Epub 2013 Aug 29.

 

UCT-derived MSC for Traumatic Brain Injury

Therapeutic Applications

Zhou HX, Liu ZG, Liu XJ, et al.; Umbilical cord-derived mesenchymal stem cell transplantation combined with hyperbaric oxygen treatment for repair of traumatic brain injury.; Neural Regen Res. 2016 Jan;11(1):107-13. doi: 10.4103/1673-5374.175054

Miao X, Wu X, Shi W.; Umbilical cord mesenchymal stem cells in neurological disorders: A clinical study.; Indian J Biochem Biophys. 2015 Apr;52(2):140-6.

Wang S, Cheng H, Dai G, et al.; Umbilical cord mesenchymal stem cell transplantation significantly improves neurological function in patients with sequelae of traumatic brain injury.; Brain Res. 2013 Sep 26;1532:76-84. doi: 10.1016/j.brainres.2013.08.001. Epub 2013 Aug 11

 

UCT-derived MSC for Autism

Therapeutic Applications

Lv YT, Zhang Y, Liu M, et al.; Transplantation of human cord blood mononuclear cells and umbilical cord-derived mesenchymal stem cells in autism.; J Transl Med. 2013 Aug 27;11:196. doi: 10.1186/1479-5876-11-196.

 

UCT-derived MSC for Hypoxic-ischemic encephalopathy (HIE)

Therapeutic Applications

Xie B, Gu P, Wang W, et al.; Therapeutic effects of human umbilical cord mesenchymal stem cells transplantation on hypoxic ischemic encephalopathy.; Am J Transl Res. 2016 Jul 15;8(7):3241-50. eCollection 2016.

 

UCT-derived MSC for Vascular Dementia

Therapeutic Applications

He Y, Jin X, Wang J.; Umbilical cord-derived mesenchymal stem cell transplantation for treating elderly vascular dementia.; Cell Tissue Bank. 2017 Mar;18(1):53-59. doi: 10.1007/s10561-017-9609-6. Epub 2017 Jan 30.

 

UCT-derived MSC for Inflammatory Bowel Disease

Therapeutic Applications

Hu J, Zhao G, Zhang L, et al.; Safety and therapeutic effect of mesenchymal stem cell infusion on moderate to severe ulcerative colitis.; Exp Ther Med. 2016 Nov;12(5):2983-2989. Epub 2016 Sep 20

Zhang J, Lv S, Liu X, et al.; Umbilical Cord Mesenchymal Stem Cell Treatment for Crohn's Disease: A Randomized Controlled Clinical Trial.; Gut Liver. 2018 Jan 15;12(1):73-78. doi: 10.5009/gnl17035.

 

UCT-derived MSC for Liver Cirrhosis, Liver Failure, Liver Injury and Liver Transplantation

Therapeutic Applications

Fang X, Liu L, Dong J, et al.; A study about immunomodulatory effect and efficacy and prognosis of human umbilical cord mesenchymal stem cells in patients with chronic hepatitis B-induced decompensated liver cirrhosis.; J Gastroenterol Hepatol. 2018 Apr;33(4):774-780. doi: 10.1111/jgh.14081.

Sang W, Lv B, Li K, et al.; Therapeutic efficacy and safety of umbilical cord mesenchymal stem cell transplantation for liver cirrhosis in Chinese population: A meta-analysis.; Clin Res Hepatol Gastroenterol. 2017 Dec 6. pii: S2210-7401(17)30259-0. doi: 10.1016/j.clinre.2017.11.003. [Epub ahead of print]

Liang J, Zhang H, Zhao C, et al.; Effects of allogeneic mesenchymal stem cell transplantation in the treatment of liver cirrhosis caused by autoimmune diseases.; Int J Rheum Dis. 2017 Sep;20(9):1219-1226. doi: 10.1111/1756-185X.13015. Epub 2017 Feb 20.

Fang XQ, Zhang JF, Song HY, et al.; Effect of umbilical cord mesenchymal stem cell transplantation on immune function and prognosis of patients with decompensated hepatitis B cirrhosis; Zhonghua Gan Zang Bing Za Zhi. 2016 Dec 20;24(12):907-910. doi: 10.3760/cma.j.issn.1007-3418.2016.12.006.

Yu SJ, Chen LM, Lyu S, et al.; Safety and efficacy of human umbilical cord derived-mesenchymal stem cell transplantation for treating patients with HBV-related decompensated cirrhosis; Zhonghua Gan Zang Bing Za Zhi. 2016 Jan;24(1):51-5. doi: 10.3760/cma.j.issn.1007-3418.2016.01.010

Xue HL, Zeng WZ, Wu XL, et al.; Clinical therapeutic effects of human umbilical cord-derived mesenchymal stem cells transplantation in the treatment of end-stage liver disease.; Transplant Proc. 2015 Mar;47(2):412-8. doi: 10.1016/j.transproceed.2014.10.048.

Wang L, Li J, Liu H, et al.; Pilot study of umbilical cord-derived mesenchymal stem cell transfusion in patients with primary biliary cirrhosis; J Gastroenterol Hepatol. 2013 Aug;28 Suppl 1:85-92. doi: 10.1111/jgh.12029

Lin H, Zhang Z, Shi M, et al.; Prospective controlled trial of safety of human umbilical cord derived-mesenchymal stem cell transplantation in patients with decompensated liver cirrhosis.; Zhonghua Gan Zang Bing Za Zhi. 2012 Jul;20(7):487-91. doi: 10.3760/cma.j.issn.1007-3418.2012.07.002

Zhang Z, Lin H, Shi M, et al.; Human umbilical cord mesenchymal stem cells improve liver function and ascites in decompensated liver cirrhosis patients.; J Gastroenterol Hepatol. 2012 Mar;27 Suppl 2:112-20. doi: 10.1111/j.1440-1746.2011.07024.x

Shi M, Zhang Z, Xu R, et al.; Human mesenchymal stem cell transfusion is safe and improves liver function in acute-on-chronic liver failure patients.; Stem Cells Transl Med. 2012 Oct;1(10):725-31. doi: 10.5966/sctm.2012-0034. Epub 2012 Oct 11.

Li YH, Xu Y, Wu HM, et al.; Umbilical Cord-Derived Mesenchymal Stem Cell Transplantation in Hepatitis B Virus Related Acute-on-Chronic Liver Failure Treated with Plasma Exchange and Entecavir: a 24-Month Prospective Study.; Stem Cell Rev. 2016 Dec;12(6):645-653

Shi M, Liu Z, Wang Y, et al.; A Pilot Study of Mesenchymal Stem Cell Therapy for Acute Liver Allograft Rejection.; Stem Cells Transl Med. 2017 Dec;6(12):2053-2061. doi: 10.1002/sctm.17-0134

Zhang YC, Liu W, Fu BS, et al.; Therapeutic potentials of umbilical cord-derived mesenchymal stromal cells for ischemic-type biliary lesions following liver transplantation.; Cytotherapy. 2017 Feb;19(2):194-199. doi: 10.1016/j.jcyt.2016.11.005. Epub 2016 Dec 8

 

UCT-derived MSC for cardiovascular diseases

Therapeutic Applications

Bartolucci J, Verdugo FJ, González PL, et al.; Safety and Efficacy of the Intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells in Patients With Heart Failure: A Phase 1/2 Randomized Controlled Trial (RIMECARD Trial [Randomized Clinical Trial of Intravenous Infusion Umbilical Cord Mesenchymal Stem Cells on Cardiopathy]); Circ Res. 2017 Oct 27;121(10):1192-1204. doi: 10.1161/CIRCRESAHA.117.310712. Epub 2017 Sep 26.

Li X, Hu YD, Chen Y, et al.; Mechanisms of Improvement of Left Ventricular Function by Intracoronary Human Umbilical Cord-Derived Mesenchymal Stem Cell Infusion in Very Old Patients with Coronary Chronic Total Occlusion.; Curr Pharm Des. 2015;21(26):3844-50.

Li X, Hu YD, Guo Y, et al.; Safety and efficacy of intracoronary human umbilical cord-derived mesenchymal stem cell treatment for very old patients with coronary chronic total occlusion.; Curr Pharm Des. 2015;21(11):1426-32.

Musialek P, Mazurek A, Jarocha D, et al.; Myocardial regeneration strategy using Wharton's jelly mesenchymal stem cells as an off-the-shelf 'unlimited' therapeutic agent: results from the Acute Myocardial Infarction First-in-Man Study.; Postepy Kardiol Interwencyjnej. 2015;11(2):100-7. doi: 10.5114/pwki.2015.52282. Epub 2015 Jun 22.

Can A, Ulus AT, Cinar O, et al.; Human Umbilical Cord Mesenchymal Stromal Cell Transplantation in Myocardial Ischemia (HUC-HEART Trial). A Study Protocol of a Phase 1/2, Controlled and Randomized Trial in Combination with Coronary Artery Bypass Grafting.; Stem Cell Rev. 2015 Oct;11(5):752-60. doi: 10.1007/s12015-015-9601-0.

Zhao XF, Xu Y, Zhu ZY, et al.; Clinical observation of umbilical cord mesenchymal stem cell treatment of severe systolic heart failure.; Genet Mol Res. 2015 Apr 10;14(2):3010-7. doi: 10.4238/2015.April.10.11.

Gao LR, Chen Y, Zhang NK, et al.; Intracoronary infusion of Wharton's jelly-derived mesenchymal stem cells in acute myocardial infarction: double-blind, randomized controlled trial.; BMC Med. 2015 Jul 10;13:162. doi: 10.1186/s12916-015-0399-z83, Bilal et al

 

UCT-derived MSC for Diabetes and hyperglycaemia-related disorders

Therapeutic Applications

Qin HL, Zhu XH, Zhang B, et al.; Clinical Evaluation of Human Umbilical Cord Mesenchymal Stem Cell Transplantation After Angioplasty for Diabetic Foot.; Exp Clin Endocrinol Diabetes. 2016 Sep;124(8):497-503. Epub 2016 May 24

Hu J, Wang Y, Gong H, et al.; Long term effect and safety of Wharton's jelly-derived mesenchymal stem cells on type 2 diabetes.; Exp Ther Med. 2016 Sep;12(3):1857-1866. Epub 2016 Jul 26.

Cai J, Wu Z, Xu X, et al.; Umbilical Cord Mesenchymal Stromal Cell With Autologous Bone Marrow Cell Transplantation in Established Type 1 Diabetes: A Pilot Randomized Controlled Open-Label Clinical Study to Assess Safety and Impact on Insulin Secretion.; Diabetes Care. 2016 Jan;39(1):149-57. doi: 10.2337/dc15-0171. Epub 2015 Dec 1.

Guan LX, Guan H, Li HB, et al.; Therapeutic efficacy of umbilical cord-derived mesenchymal stem cells in patients with type 2 diabetes.; Exp Ther Med. 2015 May;9(5):1623-1630. Epub 2015 Mar 9.

Li XY, Zheng ZH, Li XY, et al.; Treatment of foot disease in patients with type 2 diabetes mellitus using human umbilical cord blood mesenchymal stem cells: response and correction of immunological anomalies.; Curr Pharm Des. 2013;19(27):4893-9.

Hu J, Yu X, Wang Z, et al.; Long term effects of the implantation of Wharton's jelly-derived mesenchymal stem cells from the umbilical cord for newly-onset type 1 diabetes mellitus.; Endocr J. 2013;60(3):347-57. Epub 2012 Nov 16.

Kong D, Zhuang X, Wang D, et al.; Umbilical cord mesenchymal stem cell transfusion ameliorated hyperglycemia in patients with type 2 diabetes mellitus.; Clin Lab. 2014;60(12):1969-76.

Liu X, Zheng P, Wang X, et al.; A preliminary evaluation of efficacy and safety of Wharton's jelly mesenchymal stem cell transplantation in patients with type 2 diabetes mellitus.; Stem Cell Res Ther. 2014 Apr 23;5(2):57. doi: 10.1186/scrt446.

Chen P, Huang Q, Xu XJ, et al.; The effect of liraglutide in combination with human umbilical cord mesenchymal stem cells treatment on glucose metabolism and β cell function in type 2 diabetes mellitus; Zhonghua Nei Ke Za Zhi. 2016 May 1;55(5):349-54. doi: 10.3760/cma.j.issn.0578-1426.2016.05.004

Qin HL, Zhu XH, Zhang B, et al.; Clinical Evaluation of Human Umbilical Cord Mesenchymal Stem Cell Transplantation After Angioplasty for Diabetic Foot.; Exp Clin Endocrinol Diabetes. 2016 Sep;124(8):497-503. Epub 2016 May 24.

 

UCT-derived MSC for Dystrophic Muscle diseases

Therapeutic Applications

Rajput BS, Chakrabarti SK, Dongare VS, et al.; Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Duchenne Muscular Dystrophy: Safety and Feasibility Study in India.; J Stem Cells. 2015;10(2):141-56.

Yang XF, Xu YF, Zhang YB, et al.; Functional improvement of patients with progressive muscular dystrophy by bone marrow and umbilical cord blood mesenchymal stem cell transplantations; Zhonghua Yi Xue Za Zhi. 2009 Sep 29;89(36):2552-6

Li P, Cui K, Zhang B, et al.; Transplantation of human umbilical cord-derived mesenchymal stems cells for the treatment of Becker muscular dystrophy in affected pedigree members.; Int J Mol Med. 2015 Apr;35(4):1051-7. doi: 10.3892/ijmm.2015.2084. Epub 2015 Jan 30

Patel A, Riordan N.; Allogeneic transplantation of human umbilical cord mesenchymal stem cells (UC-MSC) for a single male patient with duchenne muscular dystrophy.; (DMD). Cytotherapy 2015;17:S46.

 

UCT-derived MSC for bone regeneration, non-union fractures and osteonecrosis

Therapeutic Applications

Qu Z, Fang G, Cui Z, et al.; Cell therapy for bone nonunion: a retrospective study.; Minerva Med. 2015 Dec;106(6):315-21. Epub 2015 Nov 25.

Xue G, He M, Zhao J, et al.; Intravenous umbilical cord mesenchymal stem cell infusion for the treatment of combined malnutrition nonunion of the humerus and radial nerve injury.; Regen Med. 2011 Nov;6(6):733-41. doi: 10.2217/rme.11.83.

Qu Z, Mi S, Fang G.; Clinical study on treatment of bone nonunion with MSCs derived from human umbilical cord.; Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2009 Mar;23(3):345-7

Dilogo IH, Primaputra MRA, Pawitan JA, et al.; Modified Masquelet technique using allogeneic umbilical cord-derived mesenchymal stem cells for infected non-union femoral shaft fracture with a 12 cm bone defect: A case report.; Int J Surg Case Rep. 2017;34:11-16. doi: 10.1016/j.ijscr.2017.03.002. Epub 2017 Mar 6.

Cai J, Wu Z, Huang L, et al.; Cotransplantation of bone marrow mononuclear cells and umbilical cord mesenchymal stem cells in avascular necrosis of the femoral head.; Transplant Proc. 2014 Jan-Feb;46(1):151-5. doi: 10.1016/j.transproceed.2013.06.021

Chen C, Qu Z, Yin X, et al.; Efficacy of umbilical cord-derived mesenchymal stem cell-based therapy for osteonecrosis of the femoral head: A three-year follow-up study.; Mol Med Rep. 2016 Nov;14(5):4209-4215. doi: 10.3892/mmr.2016.5745. Epub 2016 Sep 16

 

UCT-derived MSC for Lung Injury

Therapeutic Applications

Zhang C, Yin X, Zhang J, et al.; Clinical observation of umbilical cord mesenchymal stem cell treatment of severe idiopathic pulmonary fibrosis: A case report.; Exp Ther Med. 2017 May;13(5):1922-1926. doi: 10.3892/etm.2017.4222. Epub 2017 Mar 10.

Chang Y, Park SH, Huh JW, et al.; Intratracheal administration of umbilical cord blood-derived mesenchymal stem cells in a patient with acute respiratory distress syndrome.; J Korean Med Sci. 2014 Mar;29(3):438-40. doi: 10.3346/jkms.2014.29.3.438. Epub 2014 Feb 27

Liu WW, Yu W, Chen JY, et al.; Effects of human umbilical cord mesenchymal stem cells in the treatment of paraquat-induced lung injury.; Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2012 Nov;30(11):811-5

Shi D, Wang D, Li X, et al.; Allogeneic transplantation of umbilical cord-derived mesenchymal stem cells for diffuse alveolar hemorrhage in systemic lupus erythematosus.; Clin Rheumatol. 2012 May;31(5):841-6. doi: 10.1007/s10067-012-1943-2

Han DM, Wang ZD, Ding L, et al.; Effect of umbilical cord MSC infusion on the pulmonary infection in haploidentical hematopoietic stem cell transplantation.; Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2014 Aug;22(4):1084-8. doi: 10.7534/j.issn.1009-2137.2014.04.037

 

UCT-derived MSC for Skin Applications, Diseases and Disorders and wound healing

Therapeutic Applications

Leng X, Fan Y, Wang Y, et al.; Treatment of Ischemia-Reperfusion Injury of the Skin Flap Using Human Umbilical Cord Mesenchymal Stem Cells (hUC-MSCs) Transfected with "F-5" Gene.; Med Sci Monit. 2017 Jun 6;23:2751-2764

Sabapathy V, Sundaram B, Kumar S.; Therapeutic Application of Human Wharton Jelly Mesenchymal Stem Cells in Skin Injury of SCID.; Methods Mol Biol. 2017;1553:115-132. doi: 10.1007/978-1-4939-6756-8_9.

Kim HS, Lee JH, Roh KH, et al.; Clinical Trial of Human Umbilical Cord Blood-Derived Stem Cells for the Treatment of Moderate-to-Severe Atopic Dermatitis: Phase I/IIa Studies.; Stem Cells. 2017 Jan;35(1):248-255. doi: 10.1002/stem.2401. Epub 2016 Jun 28.

Chen H, Niu JW, Ning HM, et al.; Treatment of Psoriasis with Mesenchymal Stem Cells.; Am J Med. 2016 Mar;129(3):e13-4. doi: 10.1016/j.amjmed.2015.11.001. Epub 2015 Nov 12

Nan W, Liu R, Chen H, et al.; Umbilical Cord Mesenchymal Stem Cells Combined With a Collagenfibrin Double-layered Membrane Accelerates Wound Healing.; Wounds. 2015 May;27(5):134-40.

Li X, Wang D, Lu et al.; Umbilical cord mesenchymal stem cell transplantation in drug-induced Stevens-Johnson syndrome. J Eur Acad Dermatol Venereol 2013;27:659–61.